Adefovir
Synonym(s)
Adefovirdipivoxil; Adefovir Dipivoxil
Definition
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Virustatic agent from the class of nucleotidal reverse transcriptase inhibitors.
Indication
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Chronic hepatitis B in adults with decompensated liver disease or compensated liver disease with proven active viral replication, continuously elevated ALT levels and histological evidence of active hepatitis and fibrosis.
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Pregnancy/nursing period
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If possible, do not use in pregnancy (reproductive toxic effects in animal experiments, insufficient data available in patients), contraindicated in lactation.
Dosage and method of use
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once/day 1 tbl. p.o.
Remember! Stop of therapy can be considered in case of seroconversion (loss of HBeAg and HBV-DNA in case of anti-HBe detection in 2 consecutive controls!
Contraindication
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Hypersensitivity to Adefovir, Pat. < 18 years (insufficient data available, Pat. > 65 years (no studies).
Preparations
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Hepsera
Note(s)
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Remember! During therapy control of biochemical, virological and serological hepatitis B markers at least every 3-6 months!
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Prof. Dr. med. Peter Altmeyer