Hypericum perforatum

see under St. John's wort

Laif® 900 Filmtbl,

Arthrodynat® ointment, Bedan® cream, Bedan ^® face cream, Befelka® oil, Buenoson® N ointment, Dolo-cyl® oil - muscle and joint oil, Jarsin® tbl 300-750, St. John's wort ratiopharm®, Kytta ointment®, Phönox Kalophön ointment, Rhoival® tea

St. John's wort has been shown to inhibit Cyp3A4 (see cytochrome P450 enzymes below). This leads to a slower degradation of its substrates (prolongation of efficacy). Phototoxic! Caution during the summer months, no UV exposure!

1. Apaydin EA et al.(2016) A systematic review of St. John's wort for major depressive disorder. Syst Rev 5:148.
2. Becker LC et al. (2014) Amended safety assessment of Hypericum perforatum-derived ingredients as used in cosmetics. Int J Toxicol. 33(3 Suppl):5S-23S.
3. Golsch S et al (1997) Reversible increase of photosensitivity in the UVB range by St. John's wort extract preparations. Dermatologist 48: 249-252
4. Huang LF et al (2014) Hypericin: chemical synthesis and biosynthesis. Chin J Nat Med 12:81-88.
5. Reichling J et al. (2003) St. John's Wort (Hypericum perforatum L.)--multicompound preparations versus single substances. Forsch Komplementarmed Klass Naturheilkd 10(Suppl1): 28-32.
6. Saller R et al. (2003) St. John's Wort (Hypericum perforatum): a plurivalent raw material for traditional and modern therapies. Forsch Komplementarmed Klass Naturheilkd 10(Suppl1): 33-40.
7. Schempp CM et al (2003) Randomised, placebo-controlled double-blind, half-site trial Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study. Dermatologist 54: 248-253
8. Schulz V (2001) Incidence and clinical relevance of the interactions and side effects of Hypericum preparations. Phytomedicine 8:152-160.
9. Wölfle U et al (20149 Topical application of St. John's wort (Hypericum perforatum). Planta Med 80(2-3):109-120.
10. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-hypericum-perforatum-l-herba-well-established-medicinal-use_en.pdf
11. https://arzneipflanzenlexikon.info/johanniskraut.php.
12. Wenigmann M. (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp. 134-135
13. Hoffmann J ET AL. (2020) New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders. Biomedicines. 8, 27; doi:10.3390/biomedicines8020027.