Helenalin

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 27.03.2023

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Definition
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Helenalin is a natural sesquiterpene lactone with antiphlogistic and antitumor activity found in arnica species (Arnica chamissonis, Arnica montana) and other Asteraceae (greater nasturtium, elecampane).
Helenalin selectively inhibits the transcription factor NF-κB. In vitro, helenin is shown to inhibit telomerase gene expression; furthermore, the substance exhibits anti-trypanosomal and antimicrobial activity. Experimentally, the substance inhibits melanin production in melanocytes.
Helenalin is highly toxic and has considerable allergenic potency. Helenalin is the actual cause of arnica sensitization (see below Arnica), has a cardiotoxic effect in higher doses.

Literature
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  8. https://www.bundessortenamt.de/bsa/media/Files/BSL/bsl_arznei_2002.pdf