Chinese fortune tree

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Camptotheca acuminata Camptothecin , Chinese crab tree

Definition
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Camptotheca acuminata is one of three species of the genus Camptotheca within the family Tupelogewächse (Nyssaceae). It is native to the southern Chinese provinces of Guangdong, Guangxi, Guizhou, Hunan and Yunnan.

Spectrum of action
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Medical significance: From the bark and roots, seeds and wood, as well as (young) leaves of Camptotheca acuminata, Camptothecin is an alkaloid which has a special pharmaceutical significance. The highest Camptothecin content is found in the young leaves and flower buds. Camptothecin, which chemically belongs to the quinoline alkaloids, inhibits the enzyme topoisomerase I and showed a cytostatic efficacy in clinical studies. Further developments of camptothecin, the pharmaceuticals topotecan and irinotecan, are approved for the treatment of malignant tumours, camptothecin itself is not approved due to its side effects (Legarza K et al. 2005).

Literature
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  1. Legarza K et al (2005) Novel camptothecin derivatives. In Vivo 19:283-292.

Incoming links (3)

Camptothecin; Irinotecan; Topotecan;

Outgoing links (2)

Camptothecin; Topoisomerases;

Authors

Last updated on: 29.10.2020