Synonym(s)
Anti-MAG-AK
DefinitionThis section has been translated automatically.
The antibody is directed against myelin-associated glycoprotein (MAG), a glycoprotein in the cell membrane of myelin sheaths. Anti-AG-AK are involved in 50% of cases of IgM monoclonal gammopathies in the demyelisation of the affected nerve tracts.
Field of application/useThis section has been translated automatically.
Indications: Polyneuropathies in association with paraproteinemias with mostly symmetrical, distally emphasized symptoms. Polyneuropathy; especially immune-mediated polyneuropathy IFT
Comment: Anti-MAG-AK are mainly found in IgM monoclonal gammopathy before IgM-MGUS. Furthermore in M. Waldenström and other B-cell lymphomas.
LiteratureThis section has been translated automatically.
Manfras B et al (2018) Immunodiagnostics. In: Neumeister B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 430
Prof. Dr. med. Peter Altmeyer
Prof. Dr. med. Martina Bacharach-Buhles