Anti-melin associated glycoprotein-ak

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

Anti-MAG-AK

Definition
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The antibody is directed against myelin-associated glycoprotein (MAG), a glycoprotein in the cell membrane of myelin sheaths. Anti-AG-AK are involved in 50% of cases of IgM monoclonal gammopathies in the demyelisation of the affected nerve tracts.

Field of application/use
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Indications: Polyneuropathies in association with paraproteinemias with mostly symmetrical, distally emphasized symptoms. Polyneuropathy; especially immune-mediated polyneuropathy IFT

Comment: Anti-MAG-AK are mainly found in IgM monoclonal gammopathy before IgM-MGUS. Furthermore in M. Waldenström and other B-cell lymphomas.

Literature
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Manfras B et al (2018) Immunodiagnostics. In: Neumeister B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 430