Vaccination reaction T88.1

A vaccination reaction is usually understood to be harmless symptoms that can occur as part of the immune response to a vaccination.

Application of the vaccine activates the immune system and builds up protection against infection. Depending on the immunogenicity and allergenicity of the vaccine, different adverse reactions may occur depending on the reactivity and susceptibility of the vaccinated individual. Cutaneous vaccination reactions are among the most common manifestations and can take the form of local or generalized vaccination reactions.

General reactions after a vaccination include:

• Redness, swelling or pain at the injection site,
• Increase in temperature or fever,
• headache and aching limbs,
• fatigue,
• tiredness,
• nausea,
• Swelling of the lymph nodes,
• malaise.

1. Kussini J et al. (2025) Cutaneous reactions to vaccination. J Dtsch Dermatol Ges 23:195-209.