STAT2

Last updated on: 15.07.2021

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Definition
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STAT2 stands for "Signal transducer and activator of transcription 2". STAT2 is a transcription factor that is encoded in humans by the gene of the same name. STAT2 is a member of the STAT protein family. Members of this family are phosphorylated by receptor-associated kinases in response to various cytokines and growth factors. They then form homo- or heterodimers that translocate to the nucleus where they act as transcriptional activators. Related signaling pathways include the ERK-S and Erb-B signaling pathways.

General information
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Specifically, upon binding of type I IFN to cell surface receptors, activation of the JAK kinases TYK2 and JAK1 occurs. This process induces tyrosine phosphorylation of STAT1 and STAT2 and thus their activation. The phosphorylated STATs dimerize and associate with IRF9/ISGF3G. The complexes formed in each case are termed the ISGF3 transcription factor. This complex enters the nucleus where it binds to the IFN-stimulated response element(ISRE) of DNA. This activates the transcription of interferon-stimulated genes that put the cell into an antiviral state, for example.

Literature
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  1. Lee CK et al.(1999). Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes. The Journal of Experimental Medicine 190: 1451-1464.
  2. Bhattacharya S et al (1996) Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature 383: 344-347.
  3. Li X et al. (1997) Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Molecular and Cellular Biology 17: 2048-2056.
  4. Michalska A et al. (2018) A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses. Front Immunol 9:1135
  5. Uddin S et al (1995) Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. The Journal of Biological Chemistry 270: 24627-24630.
  6. Nguyen VP et al. (2002) Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. The Journal of Biological Chemistry 277: 9713-9721.

Incoming links (3)

Necroptosis; PID; STAT4;

Last updated on: 15.07.2021