Split vaccine; Split inactivated vaccine;

Split vaccines (split vaccines) belong to the dead vaccines. The administered material is no longer infectious or capable of reproducing. These are vaccines that contain only inactive antigenic components of a pathogen (usually a virus).

Examples of splat vaccines:

• Hepatitis B (recombinantly produced)
• Haemophilus influenzae type b
• Pneumococcus
• Meningococcus C, B, ACWY
• Pertussis (acellular vaccine)
• Influenza
• Human papilloma virus (HPV)
• Herpes zoster (i.m.) vaccine
• Typhoid (i.m.)

1. Hof H (2019) Active immunization. In: Hof H, Schlüter D, Dörries R, eds Duale Reihe Medizinische Mikrobiologie. 7th, completely revised and expanded edition. Stuttgart: Thieme pp.739-742.
2. Nakayama T et al. (2015) Seasonal split influenza vaccine-induced IgE sensitization against influenza vaccine. Vaccine 33:6099-6105.