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DefinitionThis section has been translated automatically.
Spherical cells are defective erythrocytes that typically occur in spherical cell anemia (Herold 2025). Instead of the usual flat, biconcave shape, the erythrocytes have a spherical shape with a smaller diameter and greater height (Leitner 2021).
EtiologyThis section has been translated automatically.
The occurrence of spherical cells is caused by hereditary spherocytosis, which leads to a change in the erythrocytes (Leitner 2021).
PathophysiologyThis section has been translated automatically.
The membrane defect in spherical cells results in a reduced membrane substance. Due to the deformation of the erythrocytes, they are recognized as defective by the spleen and phagocytosed. This significantly shortens the survival time of the spherocytes (Herold 2025).
LiteratureThis section has been translated automatically.
- Herold G et al. (2025) Internal Medicine. Herold Publishing 46
- Kasper D L, Fauci A S, Hauser S L, Longo D L, Jameson J L, Loscalzo J et al. (2015) Harrison's Principles of Internal Medicine. Mc Graw Hill Education
- Leitner A (2021) Globular cell anemia doi: https://www.netdoktor.de/krankheiten/kugelzellanaemie/
