SLCO2A1 gene

The SLCO2A1 gene (SLCO2A1 stands for Solute Carrier Organic Anion Transporter Family Member 2A1) is a protein-coding gene located on chromosome 3q22.1-q22.2.

The SLCO2A1 gene encodes a prostaglandin transporter that belongs to the 12-membrane spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and excretion of prostaglandins in numerous tissues. Associated metabolic pathways include transport of vitamins, nucleosides, and related molecules, and disruption of transmembrane transporters

Diseases associated with SLCO2A1 include:

• Primary hypertrophic osteoarthropathy, autosomal recessive (OMIM: 259100)

and

• Primary hypertrophic osteoarthropathy, autosomal dominant.

1. Lu R et al (1996) Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest 98:1142-1149.
2. Nomura T et al (2004) The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 65:973-978.