DefinitionThis section has been translated automatically.
The SH2 domain is a small protein domain that occurs in eukaryotic cells, where it performs important functions in signal transduction. It consists of about 100 amino acids. SH2 stands for "Src-homology 2". The SH2 domain represents a binding motif consisting of about 100 amino acid residues that binds to substrate proteins with high affinity and specificity, whereby their SH2 binding site consists only of a phosphorylated tyrosine residue and a few neighbouring amino acid residues.
General informationThis section has been translated automatically.
In the context of signal transduction, the SH2 domain is essential for the control of signaling proteins such as:
- C-Src
- C-Abl (oncogenes)
- Phosphotyrosyl protein phosphatases
- Cγ phospholipase
- GAP (GTPase-activating proteins).
- Phosphoinositide 3-kinases
