Noscapine

Last updated on: 24.12.2020

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Definition
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Noscapine (international non-proprietary name for (-)-α-narcotin) is a major alkaloid of the opium poppy, Papaver somniferum (3-10 %). Similar to codeine or dihydrocodeine, it has an antitussive but not analgesic effect, although the effect is somewhat weaker than that of codeine.

Unlike morphine, noscapine has a weak respiratory stimulant and bronchodilator effect. The plasma half-life of noscapine is 2.6 to 4.5 hours. The bioavailability is individually variable and is approximately 30%.

Pharmacodynamics (Effect)
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Oxidative degradation of noscapine produces the cleavage products cotarnine and opianic acid.

Indication
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Dry irritating cough. Noscapine can therefore be used to treat irritable cough in babies as young as six months.

Dosage and method of use
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Daily dose: 150mg; single dose: 50mg

Contraindication
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Children < 6 years: The medicinal product should not normally be used in this group. There are preparations which are more suitable in terms of the strength of the active substance and/or the pharmaceutical form.

Pregnancy: According to current knowledge, the medicinal product should not be used.

Preparations
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Capval (/juice, drops and dragées); Tussanil N (CH), Nosca-Mereprin (B, L); in Germany (as well as in Austria) noscapine is available as hydrochloride as a prescription substance. However, the NRF does not contain a corresponding prescription prescription.

Literature
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  1. Mahmoudian M et al. (2009) The anti-cancer activity of noscapine: a review. In: Recent patents on anti-cancer drug discovery 4: 92-97.
  2. Winzer T et al. (2012) A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine. Science 336: 1704-1708

Last updated on: 24.12.2020