DefinitionThis section has been translated automatically.
Pyrazole derivative with strong analgesic, as well as antipyretic, antiphlogistic and spasmolytic effects, which can be used as an intravenously administered alternative to other i.v. injectable non-opioids, if these cannot be used due to severe hepatic (paracetamol) or renal/cardiac risk factors ( parecoxib).
Pharmacodynamics (Effect)This section has been translated automatically.
Predominantly central inhibition of the COX-3 isoenzyme without effect on the constitutionally present COX-1; therefore no gastrointestinal damage!
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Undesirable effectsThis section has been translated automatically.
- Rare: bone marrow damage with agranulocytosis, severe anaphylactic reactions, hypotension, hyperhidrosis, possibly reddening of the urine.
- Cutaneous NW: described include urticaria, angioedema, vasculitis allergica, fixed drug exanthema, erythema exsudativum multiforme, toxic epidermal necrolysis, pustulosis, acute generalized exanthematous (AGEP).
PreparationsThis section has been translated automatically.
Novalgin, Analgin, Novamine sulfone
LiteratureThis section has been translated automatically.
- Jage J (2009) Key questions on the therapy of postoperative pain. Georg Thieme Publishing House, Stuttgart S.16-21