Metamizole

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 18.12.2020

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Synonym(s)

Noramidopyrin methanesulfonate

Definition
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Pyrazole derivative with strong analgesic, as well as antipyretic, antiphlogistic and spasmolytic effects, which can be used as an intravenously administered alternative to other i.v. injectable non-opioids, if these cannot be used due to severe hepatic (paracetamol) or renal/cardiac risk factors ( parecoxib).

Pharmacodynamics (Effect)
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Predominantly central inhibition of the COX-3 isoenzyme without effect on the constitutionally present COX-1; therefore no gastrointestinal damage!

Undesirable effects
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Preparations
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Novalgin, Analgin, Novamine sulfone

Literature
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  1. Jage J (2009) Key questions on the therapy of postoperative pain. Georg Thieme Publishing House, Stuttgart S.16-21

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Last updated on: 18.12.2020