LYST Gene

The LYST gene, also referred to as the CHS gene (LYST stands for Lysosomal Trafficking Regulator; CHS for Chediak-Higashi Syndrome) is a protein-coding gene localized to chromosome 1q42.3. Alternative splicing results in multiple transcript variants, the precise analysis of which is still pending.

Diseases associated with LYST include Chediak-Higashi syndrome and an attenuated variant of Chediak-Higashi syndrome.

1. Holland P et al. (2014) LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis. Traffic 15:1390-1405.
2. Sepulveda FE et al. (2015) LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function. Traffic 16:191-203.
3. Westphal A et al. (2017) Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses. J Exp Med 214:227-244.