Lupus nephritis - Altmeyers Encyclopedia - Department Internal medicine

Definition
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Significant organ manifestation of systemic lupus erythematosus (SLE), occurs in > 40 % of patients. Important role in mortality and morbidity of SLE, approx. 30 % do not respond to therapy, in many cases the response is delayed!

Typical representative of immune complex glomerulonephritis with deposition of mesangial and sub-endothelial immune complexes (especially DNA/anti-DNA complexes)

Multiple glomerular lesions

Variable clinical and laboratory signs

Association with anti-ds-DNA antibodies