DefinitionThis section has been translated automatically.
Rare congenital glomerulopathy with deposits of abnormal lipoproteins within the glomerulum, predominantly described in the Japanese and Chinese populations. These consist of ApoE mutants (Saito T et al. 2006).
EtiopathogenesisThis section has been translated automatically.
This is caused by mutations in the APOE gene (Kato T et al. 2019; Ku M et al. 2019) which is located on chromosome 19q13.32. The different mutations lead to pathogenic lipoproteins (see below apolipoprotein E variants)
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Clinical featuresThis section has been translated automatically.
Hyperlipoproteinemia type III; development of a glomerulopathy with proteinuria, possibly development of a nephrotic syndrome.
HistologyThis section has been translated automatically.
Kidney: Signs of a membranous nephropathy with electron dense depots in the subepithelial, subendothelial and mesangial areas.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Kato T et al (2019) A case of apolipoprotein E Toyonaka and homozygous apolipoprotein E2/2 showing non-immune membranous nephropathy-like glomerular lesions with foamy changes. CEN Case Rep 8:106-111.
- Ku M et al (2019) A novel apolipoprotein E mutation (p.Arg150Cys) in a Chinese patient with lipoprotein glomerulopathy. Chin Med J 132:237239.
- Magistroni R et al (2013) Lipoprotein Glomerulopathy Associated with a mutation in Apolipoprotein E. Clin Med Insights Case Rep 6: 189-196.
- Saito T et al (2006) Impact of lipoprotein glomerulopathy on the relationship between lipids and renal diseases. Am. J. Kidney Dis 47: 199-211.
Outgoing links (1)Apolipoprotein e variants;
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