Ldh

LDH, also called lactate dehydrogenase, is an ubiquitously occurring enzyme that catalyses the oxidation of lactate to pyruvate. LDH is formed from the genetically determined subunits H (heart type) and M (Myuekl type). 5 cytoplasmically occurring isoenzymes, LDH1-LDH5.

The ubiquitous enzyme shows the highest activity in skeletal muscles, heart muscle, kidney, brain and liver. Due to the lack of organ specificity, the enzyme is a less suitable diagnostic parameter.

Standard value:

• Adults: < 250 U/l
• Children (1-15 years): < 400 U/l
• Children < 1 year: <450 U/l

Pathologically increased: myocardial infarction, shock, pulmonary embolism, hemolysis, malignancies, myopathies, hepatic parenchyma damage, cardiac muscle damage, mononucleosis, hemolytic or megaloblastic anemia, thrombotic-thrombocytopenic purpura, acute or chronic myeloid leukemia.