LAMP2

LAMP2 is the acronym for "Lysosomal Associated Membrane Protein 2" (CD107b (Cluster of Differentiation 107b) s a and refers to a human gene located on chromosome Xq24 that encodes a lysosomal membrane glycoprotein. LAMP1 and LAMP2 make up approximately 50% of the membrane components of lysosomes. Lysosomes are compartments in the cell that digest and recycle materials. The role that the LAMP-2 protein plays in the lysosome is still unclear.

The lysosomal glycoprotein encoded by LAMP2 may play a role in tumor cell metastasis. It may also have a function in lysosome protection, maintenance and adhesion. Furthermore, this glycoprotein provides selectins with carbohydrate ligands.

There is speculation that some of the functions of LAMP2 are to protect the lysosomal membrane from proteolytic enzymes located within the lysosome. Furthermore, LAMP2 is thought to perform receptor functions for proteins and to be involved in the fusion of the autophagosome and lysosome.

Alternative splicing of the gene results in three variants:

• LAMP-2A
• LAMP-2B and
• LAMP-2C.

LAMP-2A is the receptor for chaperone-mediated autophagy. LAMP-2B is the main isoform found in the heart and muscles that serve movement (skeletal muscles).

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