Synonym(s)
KLKs
DefinitionThis section has been translated automatically.
Kallikrein-related peptidases (KLKs) play a central role in skin desquamation. They are strictly controlled by specific inhibitors. These include the lymphoepithelial Kazal type 1 inhibitor(LEKTI), which is encoded by SPINK5, and LEKTI-2, which is encoded by SPINK9. Furthermore, the protease inhibitor SPINK6 proved to be a selective inhibitor of KLKs in the skin (Meyer-Hoffert U et al. 2010).
LiteratureThis section has been translated automatically.
Chavarria-Smith J et al. (2022) Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis. Sci Transl Med 14(675):eabp9159.
- Meyer-Hoffert U et al. (2010) Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem 285:32174-32181.
