Ipratropium bromide

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

8-Methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]oct-3-yl]-3-hydroxy-2-phenyl-propanoatium bromide; CAS number: 22254-24-6 (Ipratropiumbromid); CAS number: 60205-81-4; CAS number: 66985-17-9; Muscarinic receptor antagonist; N-(2-propyl)atropinium bromide; Parasympatholytic

Definition
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Anticholinergic, bronchodilator.

Half-life
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3,2 h

Pharmacodynamics (Effect)
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Competitive antagonism of acetylcholine at the muscarinic receptor.

Indication
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Bronchial asthma, chronic obstructive bronchitis (COPD). Note:In the therapy of bronchial asthma the substance, like other muscarinic receptor antagonists, is hardly used any more.

Limited indication
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Pregnancy, nursing, tachyarrhythmia.

Dosage and method of use
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3-4 times/day 1-2 strokes per inhalation, max. 12 strokes/day.

Undesirable effects
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Allergic reactions, accommodation disorders, micturition disorders, dry mouth, glaucoma, bronchospasm.

Interactions
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Enhancement of the effect of β sympathomimetics and theophylline, enhanced anticholinergic effect in anticholinergic drugs, neuroleptics and tricyclic antidepressants

Contraindication
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Hypersensitivity to the active substance or atropine and its derivatives, narrow-angle glaucoma, prostate hypertrophy.

Preparations
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Atrovent©, Berodual©

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Last updated on: 29.10.2020