Hyperplastic polyposis syndrome D12.6

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

HPS; Hyperplastic polyps and serrated adenomas; Polyposis syndrome, hyperplastic; Serratated hyperplastic polyposis syndrome

Definition
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Rare, mostly sporadic, hitherto less well researched clinical picture associated with a significant risk of colon cancer (about 30% of patients in the collectives studied had colon cancer at initial diagnosis).

Etiopathogenesis
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The genetic causes of hyperplastic polyposis are still unknown.

Localization
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Preferably in the right colon above the sigmoid colon.

Diagnosis
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Diagnostic criteria (WHO) are currently > 30 or large hyperplastic polyps (at least 2 of 5 polyps > 1.0 cm). Evidence of hyperplastic polyposis in a first degree relative.

Differential diagnosis
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MUTYH-associated polyposis (MAP) .

General therapy
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If the number of polyps remains low, endoscopic polypectomy is the therapeutic gold standard. Because of the risk of carcinoma and a further extension of the polyposis, surgical intervention of a colectomy with proctectomy and ileo-anal anastomosis can also be recommended.

Note(s)
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The term hyperplastic polyps or serrated polyps today includes hyperplastic polyps in the narrower sense as well as sessile serrated adenomas and traditional serrated adenomas and mixed forms.

In the hyperplastic polyposis syndrome the occurrence of sessile serratified adenomas is typical. According to the current pathogenetic understanding, these have the highest potential for carcinoma development (serratated route of colon carcinogenesis).

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020