Hiatus leucaemicus refers to the absence of intermediate developmental stages within the granulopoiesis (Herold 2020).
Hiatus leucaemicus
DefinitionThis section has been translated automatically.
EtiologyThis section has been translated automatically.
Hiatus leucaemicus is a typical sign of AML = acute myeloid leukemia (Herold 2020), but can also occur in acute lymphoblastic leukemia = ALL (Lohr 2002).
HistologyThis section has been translated automatically.
Histologically, mainly blasts, promyelocytes and only very few granulocytes are found both in the blood count and in the bone marrow (Siegenthaler 2002). The intermediate stages of myelopoiesis, however, such as promyelocytes, myelocytes, metamyelocytes and rod-shaped granulocytes are not detectable (Baum 2018).
LiteratureThis section has been translated automatically.
- Baum H (2018) Hiatus leucaemicus. Lexicon of medical laboratory diagnostics. DOI: https://www.springermedizin.de/emedpedia/detail/lexikon-der-medizinischen-laboratoriumsdiagnostik/hiatus-leucaemicus?epediaDoi=10.1007%2F978-3-662-49054-9_1444
- Herold G et al (2020) Internal medicine. Herold Publishers 97,
- Kasper D L, Fauci A S, Hauser S L, Longo D L, Jameson J L, Loscalzo J et al. (2015) Harrison's Principles of Internal Medicine. Mc Graw Hill Education
- Lohr M (2002) Schwarze Reihe: Original exam questions with commentary GK2 Pathophysiology, Pathobiochemistry. Thieme Verlag Stuttgart / New York 115
- Siegenthaler W (2002) Siegenthalers Differentialdiagnose: Innere Krankheiten - vom Symptom zur Diagnose. Georg Thieme Publishers Stuttgart / New York 428