Hba1c

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Blood sugar memory; haemoglobin A1c; HBA1

Definition
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Glycated hemoglobin (glycohaemoglobin), the concentration of which depends on the concentration of blood glucose. Glycosylation is a chemical process (Amadori rearrangement) in which, unlike glycosylation, the coupling of glucose to haemoglobin A takes place without the activity of an enzyme (non-enzymatic glycation).

Corresponding to the mean survival time of the erythrocytes, the value of glycated hemoglobin is increased in the case of prolonged hyperglycaemia during the last 6-8 weeks. The colloquial term "long-term blood sugar or blood sugar memory" aptly describes the valence of an HbA1c blood concentration. The value is reduced if the life of the erythrocytes is shortened.

General information
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Standard value: < 6.2 % or < 45 mmol/mol in EDTA blood

Note(s)
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The stable form of HBA1 (ketoamine form) consists of 3 sub-fraction lakes a,b,c. The essential fraction HBA1c comprises 70% of the total ABA1 fraction and marks the patient's blood glucose metabolism with sufficient accuracy during the last 6-8 weeks.

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Glucose;

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Last updated on: 29.10.2020