DefinitionThis section has been translated automatically.
The term "fluoroquinolones" is used synonymously with gyrase inhibitors (see below gyrase inhibitors).
Fluoroquinolones, also known as gyrase inhibitors, are topisomerase inhibitors with a bactericidal effect. They inhibit the two bacterial topisomerases II (DNA gyrase) and IV. Both enzymes are responsible for the folding, twisting and correct packaging of the double-stranded ring-shaped DNA in the bacterial chromosome. They thus ensure the regular course of DNA replication and transcription. Fluoroquinolones are concentration-dependent antibiotics.
