Eosinophilic polymyositis M33.9

Last updated on: 09.10.2022

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Definition
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Eosinophilic polymyositis is one of many manifestations of the hypereosinophilia syndrome (HES). By definition, this is an idiopathic multisystem inflammatory disease characterized by blood eosinophilia (> 1,500/µl) for at least 6 months and multiple eosinophilic organ infiltrations and organ dysfunction.

Histology
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Muscle biopsy reveals a pattern similar to PM, with eosinophilic granulocytes predominating in the inflammatory infiltrate.

Diagnosis
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Characteristic features are blood eosinophilia and an increase in muscular serum enzymes and ESR. Occasionally, rheumatoid factors can also be detected.

Therapy
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Glucocorticoids in a dosage of initially 1mg/kgKG are the first choice. In case of insufficient efficacy, various immunosuppressive therapeutics are used.

Progression/forecast
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The prognosis is serious despite adequate therapy: the median survival is reported in the literature to be 9 months; on average 12% of patients live longer than 3 years.

Incoming links (1)

Hypereosinophilia syndrome;

Outgoing links (1)

Hypereosinophilia syndrome;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Last updated on: 09.10.2022