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DefinitionThis section has been translated automatically.
The chemokine receptor CCR2B, one of two isoforms of the receptor for monocyte chemoattractant protein-1(CCL2). It plays a central role in the attraction of monocytes and is involved in various chronic inflammations. An actin-binding protein known as filamin A (FLNa) interacts with the carboxyl-terminal tail of CCR2B. FLNa plays an important role in regulating the internalization and precise spatial distribution of the CCR2B receptor within dynamic membrane structures.
