Calcium modulating ligand

CAMLG (Calcium Modulating Ligand) is a protein coding gene. The gene is located on chromosome 5q31.1.

The protein encoded by this gene, also known as calcium-modulating cyclophilin ligand, (the protein functions similarly to cyclosporin A) is a signaling protein recognized by the TNF receptor TACI. Like cyclosporin A, it binds to cyclophilin B and acts downstream of TCR and upstream of calcineurin by causing calcium influx. Calcium modulating ligand is required for the stability of GET1. CAMLG stimulates calcium signaling in T cells through its involvement in increasing intracellular calcium. It is essential for the survival of peripheral follicular B cells.

1. Long T et al. (2013) A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells. Cancer Lett 339:93-101.
2. Sakai J et al (2017) The Role of BAFF System Molecules in Host Response to Pathogens. Clin Microbiol Rev 30:991-1014.
3. Yuan X et al (2008) Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol Cell Neurosci 38:277-289.