DefinitionThis section has been translated automatically.
The C21orf91 gene (C21orf91 stands for: Chromosome 21 Open Reading Frame 91) is a protein-coding gene located on chromosome 21q21.1.
General informationThis section has been translated automatically.
It is thought to be involved in the differentiation of neurons in the cerebral cortex and the positive regulation of dendritic spine development.
The C21orf91 gene is also known as "Cold Sore Susceptibility Gene-1 (CSSG-1) and may mediate susceptibility to common cold sores and HSV keratitis in humans. The C21orf91 rs10446073 genotype GT was more frequent in the HSV keratitis group than in the healthy control group. An association between herpetic keratitis and the human C21orf91 rs10446073 genotype GT can be assumed (Danileviciene V et al. 2019).
Other diseases associated with C21orf91 include enterokinase deficiency and ulcerative blepharitis.
LiteratureThis section has been translated automatically.
- Danileviciene V et al. (2019) The Role of C21orf91 in Herpes Simplex Virus Keratitis. Medicina (Kaunas) 55:753.
- Kriesel JD et al. (2011) C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene. J Infect Dis 204:1654-1662.
