Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020


APG16 Autophagy 16-Like; APG16L; ATG16 Autophagy Related 16-Like; ATG16 Autophagy Related 16-Like 1; ATG16L1 Gene; Autophagy Related 16 Like 1; Autophagy-Related Protein 1

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The protein encoded by this gene is part of a large protein complex required for autophagy. Autophagy in this context refers to an important process in which intracellular protein components in lysosomes are degraded (Lacher M et al. 1992). Defects in the ATG16L1 gene are associated with inflammatory bowel diseases such as Crohn's disease (Hampe J et al. 2007). ATG16L1 inhibits the NOD1- and NOD2-directed inflammatory cytokine reaction. Furthermore, the protein plays a role in the regulation of Paneth cell morphology and function.

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Last updated on: 29.10.2020