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Apalutamide: structural formula
apalutamide: principle of activation of the adrogen receptor after binding to its natural ligand DHT. after binding, receptor dimerization and phosphorylation occurs. the conjugate is then channelled into the cell nucleus where it can induce a DNA response with the help of a co-activator.
Apalutamide: mode of action of the adrogen receptor antagonist, which prevents AR-mediated transcription via receptor blockade.