DefinitionThis section has been translated automatically.
In idiopathic membranous glomerulonephritis, 80% of circulating antibodies against the M-type phospholipase A2 receptor protein (PLA2R1) are detected. This receptor protein is expressed in the glomerular podocytes and can also be detected in the immune depots in patients with membranous glomerulonephritis.
In 10% of cases of primary membranous glomerulonephritis, antibodies against thrombospondin type 1 domain 7A (THSD7A) are also detectable.
Increasingly, clinical data suggest that the level of antibodies correlates with disease activity. In this respect, the antibody level also serves as a progression parameter for the assessment of disease activity.
General informationThis section has been translated automatically.
Follow-up of MGN after kidney transplantation for early detection of a recurrence in the transplant.
ImplementationThis section has been translated automatically.
Test material: Serum
Reference range: immunoassay: negative
LiteratureThis section has been translated automatically.
- Böhm O et al (2018) Immunodiagnostics Thyroid hormones. In: Neumeister B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 426