Antibodies against pla2 receptor

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Phospholipase A2 receptor antibody; PLA2R1-Ak; PLA2-R-Ak

Definition
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In idiopathic membranous glomerulonephritis, 80% of circulating antibodies against the M-type phospholipase A2 receptor protein (PLA2R1) are detected. This receptor protein is expressed in the glomerular podocytes and can also be detected in the immune depots in patients with membranous glomerulonephritis.

In 10% of cases of primary membranous glomerulonephritis, antibodies against thrombospondin type 1 domain 7A (THSD7A) are also detectable.

Increasingly, clinical data suggest that the level of antibodies correlates with disease activity. In this respect, the antibody level also serves as a progression parameter for the assessment of disease activity.

General information
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Follow-up of MGN after kidney transplantation for early detection of a recurrence in the transplant.

Implementation
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Test material: Serum

Reference range: immunoassay: negative

Literature
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  1. Böhm O et al (2018) Immunodiagnostics Thyroid hormones. In: Neumeister B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 426

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Last updated on: 29.10.2020