DefinitionThis section has been translated automatically.
LKM antibodies (LKM is the acronym for "liver- kidney-microsome") recognize antigens of the cytochrome P450 system from liver and kidney. 3 different antigens can be defined: LKM-1 (Cytochrome P 450 IID6), LKM-2 (Cytochrome P 450 IIC9), LKM-3 (UDP-Gluronyltransferase). Anti-LKM antibodies (subclass LKM-1) are pathognomic for autoimmune hepatitis type 2.
ImplementationThis section has been translated automatically.
Test material: Serum
Method: IFT on kidney and liver tissue (screening test)
Immunoblot with mitochondrial or microsomal cytosolic antigens.
LiteratureThis section has been translated automatically.
- Böhm O (2018) Autoantibody diagnostics. In: Neumeier B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 424-425