Anti-Yo -antibody

Last updated on: 30.10.2022

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Definition
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Autoantibodies with a high specificity against antigens in the cytoplasm (rough ER, Golgi apparatus, cytoplasmic membrane) of Purkinje cells of the cerebellum.

Associated disease: cerebellar degeneration

Clinical picture
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Associated tumors (specificity 70-90%): Ovarian carcinoma, breast carcinoma, uterine carcinoma.

Literature
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  1. Lou Y et al. (2021) Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature. World J Clin Cases 9:4423-4432.

Last updated on: 30.10.2022