Antacids

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Definition
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Medicinal product for the treatment of complaints due to acidosis of the stomach.

For the most important antacids see Table 1.

Indication
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In dermatology, antacids play a role in particular as concomitant medication in systemic therapies with glucocorticoids as well as immunosuppressive or cytostatic therapies.

Limited indication
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Intestinal stenosis, hypophosphatemia, gastric outlet stenosis, renal insufficiency, constipation.

Undesirable effects
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CNS disorders, anaemia, appetite disorders, constipation, osteomalacia (in dialysis patients), aluminium intoxication in long-term use.

Interactions
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s. Table 2.

Tables
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Overview of the most important antacids and their dosage

Group/Active substance

Dosage

Finished preparation

Aluminium compounds

Aluminium hydroxide

3-4 times/day 2 tbl. p.o. after meals

Tepilta

Magnesium compounds

Magnesium carbonate

If required, chew or suck 1-2 tbl. finely

Palmicol

Aluminium-Magnesium Compounds

Hydrotalcite

1-2 h after the meals 2 tbl. p.o. each

Talcid

Magaldrate

4 times/day after meals 1-2 tbl. or 1 bag p.o.

Riopan

Carbaldrat

1-2 tbl/teel/btl. between meals and before bed

Compensation

Silicates

Aluminium magnesium silicopolyhydrate

Chew 2-3 tbl. intensively several times a day

Ultilac

Aluminium magnesium silicate hydrate

Suck or chew 1-2 tbl. several times a day

Gelusil

Combinations

Aluminium hydroxide-magnesium hydroxide

After the meals 1-2 tbl. or 1-2 bags p.o.

Maaloxan

Magnesium carbonate-calcium carbonate

If required 1-2 tbl., up to 3 times/day p.o.

Rennie

aluminium-magnesium-silicate hydrate + milk powder

Suck or chew 1-2 tbl. several times a day or dissolve and ingest the contents of 1-2 bags in ¼ glass of water

Gelusil-Lac


Significant interactions of antacids

Allopurinol

Allopurinol level ↓, take antacid 3 hours before allopurinol

Atenolol

Atenolol Mirrors ↓

Biphosphonates

Biphosphonate levels ↓

Chenodesoxycholic acid

Chenodesoxycholic acid levels ↓

quinine

quinine levels ↓

Cimetidine

Cimetidine level ↓, take in 2 hours intervals

Ciprofloxacin

Ciprofloxacin levels ↓

Iron

Iron Mirrors ↓

Cardiac glycosides

Glycoside levels ↓

Hydroxychloroquine

Hydroxychloroquine Mirror ↓, to be taken 4 hours apart

Isoniazid

Isoniazid mirror ↓

Itraconazole

Itraconazole level ↓, to be taken 2 hours apart

Ketoconazole

Ketoconazole level ↓, to be taken 2 hours apart

Misoprostol

Misoprostol levels ↓

Food

Fruit juices and wine increase toxicity of Al-containing antacids

Sodium fluoride

Sodium fluoride level ↓, take at intervals of 2 hours

Ofloxacin

Ofloxacin levels ↓

Propanolol

Propanolol levels ↓

Phenytoin

Phenytoin levels ↓

Rifampicin

Rifampicin levels ↓

Tetracyclines

Tetracycline level ↓, to be taken 3 hours apart

Ursodeoxycholic acid

Ursodeoxycholic acid levels ↓

Incoming links (1)

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Last updated on: 29.10.2020