Alpha1-microglobulin $$

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

protein HC

Definition
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Alpha1 microglobulin, also known as protein HC, is a low-molecular glycoprotein with immunosuppressive properties.

Its synthesis takes place in liver and lymphocytes. Due to its small molecule size (33,000 Daltons), alpha1-microglobulin is glomerularly filtered and reabsorbed in tubular form. In case of nierein insufficiency the protein accumulates in serum.

In the case of functional disorders of the renal tubules, alpha1-microglobulin is excreted in increased amounts in the urine, which makes damage to the tubules detectable.

General information
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In the case of functional disorders of the renal tubules, alpha1-microglobulin is excreted in increased amounts in the urine, which makes the damage to the tubules detectable. The urine concentration of α1-microglobulin is therefore a biomarker of renal function. The urine concentration of alpha1-microglobulin is used as a marker for the detection of tubular damage to the kidney.

Note(s)
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test material: serum, urine

Proteinuria: Identification of tubular disorders

Reference ranges:

  • Serum: <5mg/dl
  • Urine: <13mg/l

Increased serum levels: reduced glomerular function

Elevated urinary value: marker for tubular proteinuria; e.g. in interstitial nephritis, acute pyelonephritis, toxic damage to the kidneys e.g. after administration of analgesics, cytostatics or aminoglycosides.

Literature
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Neumeister B (2018) Thyroid hormones. In: Neumeister B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 107-108

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Last updated on: 29.10.2020