Ak against pla2 receptor and thsd7a $$$

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Antibodies against PLA2 receptor; Anti-GBM; PLA2-RAK

Definition
This section has been translated automatically.

Antibodies raised against glomerular basement membrane are found in the serum of about 75% of patients with idiopathic membranous glomerulonephritis (MGN), THS-D7A-AK at 2.5-5.0%.

Both AK are expressed on the podocyte membrane. PLA2R-R-AK show a high sensitivity (78%) and specificity (99%) with respect to MGN

General information
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  • DD of nephrotic syndrome: Idiopathic membranous glomerulonephritis (MGN)
  • Follow-up to assess the disease activity
  • Follow-up to assess a possible recurrence after kidney transplantation
  • Test material: Serum
  • Reference range:negative

Literature
This section has been translated automatically.

  1. Manfras B (2018) Immunodiagnostics. In: Neumeister B et al (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 426

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Last updated on: 29.10.2020