Ak against glomerular basement membrane $$$

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Anti-GBM; Goodpasture AK

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antibodies directed against type IV collagen of the glomerular basement membrane. Then there are AK that capture other epitopes, or AK against entactin, laminin and other intermediate filaments.

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AK detection in serum: A positive ELISA test is the diagnostic criterion.

Immunohistological detection: Typical linear IgG deposits on the basement membrane. Target AG is the C-terminus of the alpha3(IV) chain of type IV collagen in the alveolar and glomerular basement membrane

Differential diagnosis
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Differential diagnosis of the autoantibody spectrum in pulmonary syndromes

  • Anti-GBM-AK (Goodpasture's syndrome, anti-GBM glomerulonephritis)
  • cANCA /IFT, ELISA (Wegener's granulomatosis, idiopathic RPGN
  • pANCA/IFT,ELISA (microscopic polyarteritis, Churg-Strauss syndrome; idiopathic RPGN
  • Anti-ds-DNA (Lupus erythematosus)
  • Cryoglobulins (Cryoglobulinemia)
  • Without Auto-AK (Purpura Schoenlein-Henoch, Postinfectious Glomerulonephritis

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  1. Böhm B (2018) Thyroid hormones. In: Neumeister B et al (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 421-422


Last updated on: 29.10.2020