DefinitionThis section has been translated automatically.
The ADD1 gene (ADD1 stands for Adducin 1) is a protein coding gene located on chromosome 4p16.3.
General informationThis section has been translated automatically.
The proteins encoded by this gene, the family of adducins are cytoskeletal proteins encoded by three genes (alpha, beta and gamma). Adducin acts as a heterodimer of the related alpha, beta or gamma subunits.
The protein encoded by the ADD1 gene represents the alpha subunit. Alpha and beta adducin comprise a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C.
Clinical pictureThis section has been translated automatically.
Diseases associated with ADD1 include:
- Essential hypertension
- Tracheoesophageal fistula.
LiteratureThis section has been translated automatically.
- Liao X et al (2015) Association of alpha-ADD1 Gene and Hypertension Risk: A Meta-Analysis. Med Sci Monit. 2015 Jun 4;21:1634-41.