Activation-induced deaminase

Last updated on: 29.08.2021

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Activation-induced deaminase" abbreviated AID or AICDA is an RNA-editing deaminase belonging to the family of cytidine deaminases (DNA deaminase), which catalyze the deamination of cytosine residues in single-stranded DNA (Muramatsu M et al. 1999).The coding gene of the same name is located on chromosome 12p13.31.

General information
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AICDA is specifically expressed in germinal center-like B cells where it is enzymatically active. Although the activity of AID is essential for antibody diversification, it can be harmful to the organism under certain circumstances, as it can directly induce genomic instability and thus have a mutagenic effect.

Deaminase is involved in somatic hypermutation (SHM), gene conversion and class switch recombination (CSR) in B lymphocytes. For further information see below. ACIDA gene.

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  2. Durandy A et al (2006). Activationinduced cytidine deaminase: structure-function relationship as based on the study of mutants. Hum Mutat 27: 1185-1191.
  3. Fagarasan S et al. (2002) Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298: 1424-1427.
  4. Muramatsu M et al. (1999) Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 274: 18470-18476.
  5. Nambu Y et al (2003) Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302: 2137-2140.
  6. Okazaki I et al (2002) The AID enzyme induces class switch recombination in fibroblasts. Nature 416: 340-345.
  7. Revy P et al (2000) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102: 565-575.

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Last updated on: 29.08.2021