Abcc2 gene

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

ATP-binding cassette subfamily C member 2; MRP2/CMOAT gene; MRP2 gene; Multidrug resistance associated protein 2 gene; Multispecific organic anion transporter, canalicular, CMOAT

Definition
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The ABC2 gene codes for an ATP-dependent transporter in the apical membrane (Multidrug resistance-associated protein 2 - MRP2) which enables the efflux of bilirubin glucuronides and other organic anions from the liver cell into the bile ducts. It is cytogenetically localized on chromosome 10q24.2 (Toh S et al. 1999). ABCC2 or also called MRP2 is an integral 190 kD heavy membrane glycoprotein that is mainly expressed in the canalicular (apical) membrane of liver cells. It belongs to the superfamily of ATP-binding cassette transporters and transports endogenous and exogenous anionic conjugates (mainly bilirubin, but also various drugs) from the hepatocyte to the bile (Pacifico L et al. 2010). ABCC2 is also involved in the resistance of cancer cells to chemotherapeutic drugs (Mor-Cohen et al. 2001).

Literature
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  1. Mor-Cohen R et al (2001) Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J. Biol. chem. 276: 36923-36930
  2. Pacifico L et al (2010) Mutational analysis of ABCC2 gene in two siblings with neonatal-onset Dubin syndrome. (Letter) Clin. Gene. 78: 598-600
  3. Toh S et al (1999) Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am. J. Hum. Genet. 64: 739-746.

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Last updated on: 29.10.2020