Uroplakine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Uroplakins are transmembrane proteins in the cover cells of the urothelium. They belong to the group of the "transmembrane 4 superfamily" also known as tetraspanin family. Most of these proteins are "cell-surface proteins" characterized by 4 hydrophobic domains. Uroplakins are responsible for the mechanical chemical resistance of the urinary tract.

The uroplakin-3a antibody is a good marker for primary and metastatic urothelial carcinomas.

Literature
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  1. Truong LD et al.(2011) Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med 135:92-109.

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Last updated on: 29.10.2020