Trichilemmal carcinoma C44.L
Synonym(s)
malignant tricholemmoma; trichilemmoma malignes; Tricholemmal carcinoma
History
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Headington, 1976
Definition
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Rare, low malignant carcinoma originating from hair follicles, which histologically mimics tricholemmoma structures, see also Hair follicle tumor.
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Manifestation
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Occurring in old age.
Localization
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Located in chronically light-exposed areas (face, ear, neck).
Clinic
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Uncharacteristic: Relatively rapidly growing, 0.5-2 cm large, erosive-wetting or crusty, exophytic tumor.
Histology
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Infiltrating and destructively growing tumor of lobular, usually well-defined structure of differently sized, bright, optically empty cells with chromatin-tight nuclei. Significant cell and nuclear polymorphism, atypical mitoses. Occasional abortive hair formation.
Differential diagnosis
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- Clinical presentation: Basal cell carcinoma, cornu cutaneum, keratosis actinica.
- Histological: follicular poroma, tricholemmoma, carcinoma of the sebaceous glands.
Therapy
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Surgical removal in healthy people (safety distance about 3 mm).
Progression/forecast
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Favourable: In the long term only local growth, very rarely metastasis in the regional lymph nodes.
Literature
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- Headington JT (1976) Tumors of the hair follicle. A review. On J Pathol 85: 481-514
- Misago N et al (2002) Tricholemmal carcinoma in continuity with trichoblastoma within nevus sebaceus. At J Dermatopathol 24: 149-155
- Schell H et al (1986) Tricholemmal carcinoma. Dermatologist 37: 384-38
- Van Zele D et al (2002) Invasive tricholemmal carcinoma of the nose. Dermatology 204: 315-317
Recommended articles
Incoming links (4)
Pilomatrix carcinoma; Sebaceous gland carcinoma; Sebaceous gland carcinoma; Trichilemmoma, malignant;Outgoing links (7)
Actinic keratosis; Basal cell carcinoma (overview); Cornu cutaneum; Hair follicle tumor; Inverted follicular keratosis; Sebaceous gland carcinoma; Trichilemmoma;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
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Prof. Dr. med. Peter Altmeyer