Topoisomerase inhibitors
Synonym(s)
Topisomerase inhibitors
Definition
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Cytostatic drug; inhibitor of the enzyme topoisomerase.
Field of application/use
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There are 2 types of effect:
- Inhibitors of topoisomerase I (irinotecan, topotecan) and
- Inhibitors of topoisomerase II(etoposide, teniposide).
Indication
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Dermatological indications exist for etoposide:
- cutaneous lymphomas
- Metastatic melanoma
- Metastasized Merkel cell carcinoma.
Literature
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- Lim DS et al (2003) Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Chemotherapy 49: 257-263
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Prof. Dr. med. Peter Altmeyer