Tipranavir
Definition
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Virustatic. Inhibitor of HIV protease. Non-peptide protease inhibitor.
Pharmacodynamics (Effect)
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Inhibition of the HIV-1 aspartyl protease and suppression of the maturation of virus particles in the host cell
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Indication
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In combination with low-dose ritonavir for antiretroviral combination therapy of HIV-1 infection in multi-treated adult patients with viruses resistant to multiple protease inhibitors.
Dosage and method of use
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2 times/day 500 mg p.o. each in combination with ritonavir 100 mg p.o.
Undesirable effects
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Very often: diarrhoea, nausea. Also: headaches, stomach aches, skin changes. Liver toxicity (increased transaminases).
Preparations
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Aptivus