Temozolomide
Definition
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Cytostatic agent. Perorally administered, liquor-continuous alkylane.
Indication
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- Approved for the treatment of initially diagnosed glioblastoma multiforme concomitant to radiotherapy and subsequently as monotherapy as well as for recurrent or progressive malignant glioma after standard therapy, e.g. glioblastoma multiforme or anaplastic astrocytoma.
- Malignant melanoma ( off-label use).
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Pregnancy/nursing period
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Contraindicated.
Dosage and method of use
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Melanoma, malignant ( off-label use): 150-200 mg/m2 KO/day p.o. for 5 days, every 4 weeks
Undesirable effects
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- Very common: nausea, vomiting, constipation, anorexia, headache and fatigue, seizures (for brain tumors).
- Common: neutropenia, thrombocytopenia, lymphopenia, leucopenia, herpes simplex infections, candida stomatitis, infectious diseases, anxiety, emotional instability, insomnia.
Contraindication
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Hypersensitivity to dacarbazin (DTIC), severe myelosuppression.
Preparations
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Temodal
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Prof. Dr. med. Peter Altmeyer