Syphilide - Altmeyers Encyclopedia - Department Dermatology

Definition
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Inflammatory changes in the skin and/or mucous membranes of the secondary and tertiary stages of acquired syphilis.
The secondary period (syphilis II) is characterized by intermittent, asymptomatic (no or only slight itching), macular exanthema, which may have a very different clinical morphology (acne-like, anular, bullous, lichenoid, pustular, etc.).
With increasing duration of the disease, an increasing infiltration of the still symptomless efflorescences is typical (maculo-papular exanthema - papular exanthema -s.u. syphilis acquisita).
The changes of the tertiary period (syphilis III) have a no longer symmetrically arranged appearance with mostly large yellow-brown or brown plaques or nodules.