Β-sympathomimetics, inhalative

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 13.09.2021

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Definition
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Sympathomimetics used for bronchial or nasal application.

Indication
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  • Rhinitis allergica for short-term (3-5 days) symptomatic relief of nasal congestion.
  • Bronchial asthma, demand-oriented.

Limited indication
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Pregnancy, children < 3 years, arteriosclerosis, diabetes mellitus, cardiac arrhythmia, severe hypertension, thyroid disease, pheochromocytoma, taking MAO-A inhibitors, fresh myocardial infarction.

Undesirable effects
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Drug addiction, optical and acoustic hallucinations, nervousness, sleep disorders, subtle tremor, blurred vision, cardiac arrhythmia, impaired nasal breathing, dryness of the nose, nasal burning, damage to the nasal mucosa during long-term use, allergic reactions.

Interactions
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See Table 1.

Contraindication
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Hypersensitivity to the active substance, severe heart disease, ozaena, rhinitis sicca.

Tables
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Major interactions of inhaled β-sympathomimetics.

Anesthetics

Reciprocal toxicity ↑

Antidepressants, tricyclic

Blood pressure elevation

Guanethidine

Blood pressure elevation

Insulin

Reciprocal toxicity ↑

MAO-A inhibitors, irreversible

RR drop, cardiac arrhythmias, avoid combination.

Metformin

Hyperglycemia

Propanolol

Reciprocal toxicity ↑

Reserpine

Blood pressure elevation

Sulfonylureas

Hyperglycemia

Incoming links (3)

Oxymetazoline; Phenylephrine; Tetryzolin;

Outgoing links (2)

Allergic rhinitis; Ozaena;

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Last updated on: 13.09.2021