Sulfasalazine

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 23.12.2020

Dieser Artikel auf Deutsch

Synonym(s)

Salazosulfapyridine

Definition
This section has been translated automatically.

Half-life
This section has been translated automatically.

8 h or 2,7-10 h (metabolites).

Indication
This section has been translated automatically.

M. Crohn's disease (see regional enteritis), ulcerative colitis, rheumatoid arthritis, seronegative spondarthritis (psoriatic arthritis), majoraphthae.

Limited indication
This section has been translated automatically.

Pregnancy, lactation, glucose-6-phosphate dehydrogenase deficiency, children < 2 years, thyroid dysfunction.

Dosage and method of use
This section has been translated automatically.

Gradual dosage of 500 mg p.o. twice a day or rectally for 14 days, then increase to 500 mg three times a day for 14 days, then 1000 mg twice a day, maximum dose 3 g/day.

Notice! Caution with glucose-6-phosphate dehydrogenase deficiency. During the first months of therapy control of BB and diff. BB, transaminases, creatinine every 14 days, later every 4 weeks to 3 months. Additionally every 6 months control of antinuclear antibodies in serum!

Undesirable effects
This section has been translated automatically.

5-50% of patients have side effects, mostly dose-dependent at doses > 4 g/day or serum levels > 50 μg/ml.

  • Cutaneous side effects: Among others, allergic reactions, photosensitization, drug-induced LE, triggering of pemphigus vulgaris.
  • Extracutaneous side effects: Alveolitis, bronchospasm, BB changes, methemoglobinemia, gastrointestinal disturbances, hepatitis, cholestasis, exacerbation of ulcerative colitis, pancreatitis, parotitis, oliguria, hematuria, yellow-orange discoloration of urine, nephrotic syndrome, vasculitis, hypospermia, hypertension, palpitations, myocarditis, headache, depression, neuropathy, paresthesias, yellow-orange discoloration of contact lenses, visual, hearing and taste disturbances, induction of acute porphyria.

Interactions
This section has been translated automatically.

See Table 1.

Contraindication
This section has been translated automatically.

For example exfoliative dermatitis, haemoglobin anomalies, haemolytic anaemia, ileus, severe liver or kidney damage, paragroup allergy in children, acute hepatic porphyria, hypersensitivity to sulphonamides or salicylates.

Preparations
This section has been translated automatically.

Azulfidines

Patientinformation
This section has been translated automatically.

Contact lens wearers should be informed about the possibility of yellow-orange discoloration of contact lenses!

Tables
This section has been translated automatically.

Significant interactions of sulfasalazine

Anion exchange resins

Sulfasalazine levels ↓

Coumarins

Bleeding tendency ↑

Phenytoin

Phenytoin effect ↑

Sulfonylureas

Hypoglycaemia

Authors

Last updated on: 23.12.2020