Synonym(s)
ROS
DefinitionThis section has been translated automatically.
- Metabolic state in which a quantity of reactive oxygen compounds exceeding the physiological level is formed (ROS). Reactive oxygen compounds ("reactive oxygen species") are e.g.:
- superoxide anion radical O2-
- hydrogen peroxide (H2O2)
- Hydroxyl radical OH-
- ROS are formed during metabolic processes of the mitochondrial electron transport chain and cytochrome P50 oxidases.
- The consequences of oxidative stress include:
- disturbances in lipid peroxidation (important for the formation of cell membranes)
- oxidative protein modifications
- Damage to the DNA.
Note(s)This section has been translated automatically.
The influence of reactive oxygen species (ROS) seems to play a role in the pathogenesis of various neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS). Likewise with versch. Cardiovascular diseases such as arteriosclerosis or coronary heart disease, as the oxidation of LDL in the endothelial cells is considered important for the initiation of arteriosclerotic plaque formation. However, the benefits and effects of antioxidants in therapy are controversial.
LiteratureThis section has been translated automatically.
- Seiler A et al (2008) Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death. Cell Metabolism 8: 237-248
Prof. Dr. med. Peter Altmeyer