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Sebaceous gland hyperplasia D23.L

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 26.10.2025

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Synonym(s)

Adenoma sebaceum senile; circumscribed senile sebaceous hyperplasia; sebaceous hyperplasia; sebaceous hyperplasia circumscribed senile; senile sebaceous nevus

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DefinitionThis section has been translated automatically.

Most frequent benign adnexal tumor with differentiation of sebaceous glands.

EtiopathogenesisThis section has been translated automatically.

Immunosuppression (e.g. after taking Ciclosporin) is a favorable factor.

Hormonal or genetic influences (e.g. as part of Muir-Torre syndrome) are also cited.

ManifestationThis section has been translated automatically.

Occurs after the age of 35, especially in seborrhoics. Men are more frequently affected than women.

LocalizationThis section has been translated automatically.

Face, forehead, sides of the cheeks.

ClinicThis section has been translated automatically.

Mostly multiple, then disseminated, more rarely solitary, 0.2-0.5 cm in size, skin-colored, yellowish-reddish or yellow, centrally always forked(caution! clinically important sign; DD basal cell carcinoma!), flat or calotte-shaped, smooth papules, which show a lobular structure and a shiny surface when viewed from the side (and under reflected light microscopy) and illuminated.

Less common are 0.5-1.0 cm large, solitary papules or nodules with a mostly bumpy surface structure.

Mostly clear, accompanying seborrhoea oleosa with prominence of the skin pores.

HistologyThis section has been translated automatically.

Symmetrical tumour protruding the mostly unchanged epidermis, in which mature, hyperplastic sebaceous gland lobules are grouped around a central, dilated infundibulum filled with horny and sebaceous masses. Pityrosporon oval or bacterial clusters are often found in the retinal masses.

Differential diagnosisThis section has been translated automatically.

Clinic: Basal cell carcinoma, molluscum contagiosum

Histology: Adenoma of the sebaceous glands.

TherapyThis section has been translated automatically.

For cosmetically disturbing lesions, treatment with laser (possible options are: Erbium YAG laser, the long-pulsed 1064 nm Nd:YAG laser (e.g. Derma VTM ) or theCO2 laser), cryosurgery (established procedure in many practices) or excision (rare indication).

Note(s)This section has been translated automatically.

Confluent sebaceous gland adenomas, which cover almost the entire neck and clavicle region, are to be considered as malformation. The nosological value of the diffuse presenile sebaceous gland hyperplasia remains to be seen.

LiteratureThis section has been translated automatically.

  1. Finan MC, Apgar JT (1991) Juxta-clavicular beaded lines: a subepidermal proliferation of sebaceous gland elements. J Cutan catholic 18: 464-468
  2. Kaufmann R (1987) Diffuse (presenile) sebaceous gland hyperplasia, a new entity? dermatologist 38: 31-35
  3. Zouboulis C et al (2003) Ciclosporin A - induced sebaceous glands hyperplasia. Br J Dermatol 149: 198-200

Authors

Last updated on: 26.10.2025

Author: Prof. Dr. med. Peter Altmeyer